My little brother, or rather, one of them, starred in his school’s production of “Sessical: The Musical,” performed this past weekend. It was a great performance – quite professionally done, considering everyone in the cast was a 7th or 8th grader.
One theme evident in Seussical was alienation in one’s world; indeed, one of the songs, sung twice and echoed back to many other time, was “Alone in the Universe” -
I’m alone in the universe.
So alone in the universe.
I’ve found magic but they don’t see it
Horton sings this after being mocked for believing a person is living on the dust speck he found, referring back to the story Horton Hears a Who.
It’ quite poignant, really. Horton had good reason to feel that way; he was being emotionally and physically cut off from his social group (the other creatures in the Jungle Of Nool). But one can feel that way even if they aren’t being publically derided and excluded.
I was considering this idea, being so alone. I believe everyone feels this way sometimes; perhaps some more than others, but I believe it is shared unanimously; after all, how else could it be so common a theme, found in literature, art, and yes, Broadway musicals.(PS: Is this a theme that is universal in human existence or has appeared and increased in the modern era?)
This is quite complicated, I discovered. Humans are super-social beings; we don’t do so well in isolation, and you notice we aggregate in the same places and buildings, tending to cluster together rather then spread apart (which goes against nature as it increases the entropy of the system, but oh well there goes Tonia on a nerdy tangent).
Yet, we are all unique – thanks to random gamete selection, crossing over, and mutation, most of us have different genomes; even twins, who share the same genetic material, express it differently as they interact with their environment. We all look different, have our own thoughts, and our own unique little characteristics. In The Incredibles, the young super-hero child complains that when everyone is “super”, then “no one is.” So, we are all uniform in our unique-ness. Yet we feel alone.
—So, funny story. I began this draft early this morning. Just an hour later, in Cell Bio, our professor explained to us that the genetic differences between people are so small they are statistically negligible. How about that! It boggles my mind. Basically what that means is that a tiny, tiny, fraction of our genetic material dictates differences between us, and those differences are magnified or smoothed over by our relative experiences – and I don’t just mean experiences that you are aware of and become memory. For example, the chemical composition of your surroundings in utero can have a big effect on you later – I believe this fact explains to a certain extent the differences between identical twins.
So, anyways, we are these members of a species who are pretty much identical at a molecular level, yet each rather unique in our feelings and activities, roving around in big packs, and feeling alienated all the while. Phew. There’s some pretty deep psychology and philosophy that goes into that one, which I do not understand (yet)/won’t go into now. Just revel in the facts, without asking why.
Speaking of reveling in the facts, consider, as I said before, that some people feel more “alone” than others – and this doesn’t necessarily mean they are a social outcast or are that different. Hmmm… meaning the first-person experience can be in quite independent of third-person reality.
So, ponder that.
And thus concludes today’s rambling about human nature.
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Pia, I have to say — your ability to combine medical knowledge with philosophical reflection seems promising to me.
Just my two cents.
Interesting point about genetic similarity between humans – it must be so because otherwise we’d have trouble reproducing, I suppose!
When your professor says that the differences between humans are statistically insignificant, what does that mean? Which loci were used? What statistical test(s) were used?
I’m just curious.
…..
Maybe I just need to find the article.
I believe that is based on the sequencing of various parts of the genome. There are few enough single nucleotide polymorphisms that, when taken all into account, they add up to a very very small number and thus very little difference between people.
….
Of course, one has to consider that half of your DNA is repeating sequences, a large chunk is introns that are removed in RNA processing, and that all in all, as our professor has iterated and reiterated, only about 2-3% of your DNA actually ends up coding for proteins (there *is* other DNA that codes for small RNAs whose function is not entirely udnerstood). I’m not sure if the “statistically insignificant difference” takes into account the whole genome or only those parts that are coding/whose sequences “matter”.
….
Another interesting thought is that mutations in introns and other non-coding areas are generally conserved – if the DNA doesn’t ultimately code for anything, a mutation will not result in a protein/RNA change that could harm the organism. As I’m sure you know, this is very different in coding areas where similarities between organisms are much closer as a mutation is more likely to cause removal of that organism from the gene pool. Therefore much of the “difference” between genomes could be in areas that don’t “matter,” if the whole genome is taken into account.
It is a little intimidating to step up after that high-powered scientific terminology, but I would like to offer a comment on the question you posed: whether isolation and loneliness are more of a modern phenomenon or has it always been that way for humans? I think isolation and loneliness are definitely more widespread today than in past times. Families were bigger and lived closer 100 years ago and interaction with other people was more frequent and intense. The best story about modern day isolation that I know is Camus’s novel The Stranger. The “hero” is a strange, inward-looking, isolated individual, and in Camus’s eye represents the modern problem of alienation. I have felt it myself. GF